We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
Read More
7
Antioxidants may aid cardiovascular health
Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
Read More
7
Selenium may reduce platelet function
Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.
Our study explored how selenium influences the interaction between platelets and endothelial cells, especially regarding blood clot formation. We noticed that selenium supplementation increased the activity of protective enzymes in both platelets and endothelial cells.
Interestingly, we found that platelets showed reduced aggregation in the presence of selenium-rich endothelial cells. However, this effect was nullified when we used aspirin, indicating a complex relationship. Ultimately, while selenium shows promise, we did not find significant improvements in nitric oxide levels linked to clot prevention.
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Most Useful Reviews
9
Essential for thyroid
5 people found this helpful
I take this selenium as prescribed for my thyroid condition. It has no taste or smell, yet its benefits are vast. Selenium is crucial for the body's organs, boosts immune function, and possesses antioxidant and anti-inflammatory properties. It strengthens blood vessels, reducing plaque risk and protecting the heart. It also aids muscle and skin cell regeneration and improves gastrointestinal health.
Read More
9
Blood thinning benefits
3 people found this helpful
This microelement thins the blood, thus preventing blood clots and reducing bad cholesterol levels. Selenium helps prevent atherosclerosis and positively affects the nervous system while offering anti-inflammatory benefits, assisting with asthma. I consistently use this selenium for my family's health.
Read More
7.5
Helps muscle weakness
2 people found this helpful
If you're dealing with thyroid issues, especially autoimmunity, consult your doctor about this! I have Hashimoto's, and it's helped me immensely. After a couple of months on two tablets daily, my muscle weakness and twitches have significantly decreased. They are easy to swallow and are well absorbed, as shown in my blood work.
We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
Read More
9.5
Ebselen delays blood clot formation
Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
Read More
9
Selenium polymer reduces blood clots
Multifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications.
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
Read More
8
Enhanced imaging for carotid thrombosis
High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging.
We investigated how selenium-based nanomaterials boost photoacoustic imaging to identify carotid artery blood clots more effectively. By using a thrombosis model in mice, we found that these nanocomposites significantly enhanced imaging signals—up to 5 times greater—which helps diagnose the extent of carotid atherosclerosis.
This research suggests that selenium/polypyrrole nanoparticles may be a promising tool for improving the detection and diagnosis of carotid thrombosis, potentially leading to better stroke prevention strategies.
Read More
7
Antioxidants may aid cardiovascular health
Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
I take this selenium as prescribed for my thyroid condition. It has no taste or smell, yet its benefits are vast. Selenium is crucial for the body's organs, boosts immune function, and possesses antioxidant and anti-inflammatory properties. It strengthens blood vessels, reducing plaque risk and protecting the heart. It also aids muscle and skin cell regeneration and improves gastrointestinal health.
Read More
9
Blood thinning benefits
3 people found this helpful
This microelement thins the blood, thus preventing blood clots and reducing bad cholesterol levels. Selenium helps prevent atherosclerosis and positively affects the nervous system while offering anti-inflammatory benefits, assisting with asthma. I consistently use this selenium for my family's health.
Read More
7.5
Helps muscle weakness
2 people found this helpful
If you're dealing with thyroid issues, especially autoimmunity, consult your doctor about this! I have Hashimoto's, and it's helped me immensely. After a couple of months on two tablets daily, my muscle weakness and twitches have significantly decreased. They are easy to swallow and are well absorbed, as shown in my blood work.
Read More
8.5
Boosts immunity
1 people found this helpful
Selenium, though not widely recognised, is a crucial trace element that aids in synthesising selenoproteins with antioxidant properties. It combats free radicals, curbs inflammation, and enhances skin health. Selenium is essential for cardiovascular wellbeing and can prevent heart disease by avoiding arterial blockage and bolstering blood vessel walls.
Read More
7.5
Quality supplementation
1 people found this helpful
High-quality selenium thins the blood to reduce the risk of blood clots and lowers bad cholesterol levels. It effectively prevents atherosclerosis, supports the nervous system, and offers anti-inflammatory properties, aiding in asthma symptom relief.
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Selenium is a powerful and widely used open-source tool designed for automating web applications for testing purposes. It enables developers and testers to write code in various programming languages such as Java, Python, C#, and Ruby to simulate user interactions with a web browser. Selenium's flexibility allows users to create complex test scenarios that mimic real-world user behaviors, making it an essential tool for ensuring web application functionality and performance.
In addition to its core functionalities, Selenium consists of several components, including Selenium WebDriver for automating browsers, Selenium Grid for running tests across multiple machines and environments in parallel, and Selenium IDE for record-and-playback test creation. Its compatibility with multiple browser types—such as Chrome, Firefox, Safari, and Edge—makes it a versatile choice for automated testing, catering to a wide range of projects and team needs. For anyone involved in web development or quality assurance, understanding and utilizing Selenium can significantly improve testing efficiency and reliability.
Based on user reviews, the time it takes to see results from taking selenium for blood clot prevention can vary. Many users report experiencing benefits within a few weeks to a couple of months. For instance, one user noted improvements in muscle issues after about two months of consistent use of two tablets daily Read Review. Another user mentioned feeling a little better overall after one month, although the effects were not as pronounced as hoped Read Review.
Several reviews emphasize that selenium helps in thinning the blood and reducing the risk of clots, which may take time to manifest as measurable health benefits. For example, it was highlighted that selenium might improve blood flow and reduce cardiovascular risks over a longer course of supplementation Read Review. Overall, while individual experiences will vary, most users suggest a time frame of at least a month or more to observe noticeable improvements in their health, particularly for blood-related concerns.
The research surrounding selenium and its potential benefits for blood clot treatment is promising and multifaceted. A study highlighted the innovative use of selenium-based nanosheets that can effectively dissolve blood clots under ultrasound, outperforming standard clinical drugs without the bleeding risks typical of traditional therapies [1]. Additionally, ebselen, a selenium compound, demonstrated the ability to significantly delay thrombus formation in rats, suggesting it may be effective in reducing blood clot risk, especially under oxidative stress [5]. These findings paint a hopeful picture for selenium as a key player in blood clot management.
Further studies have also shown that selenium can influence platelet function, potentially reducing aggregation and, therefore, the risk of clot formation. Research indicated that selenium supplementation in selenium-deficient individuals resulted in increased enzyme activity that helps manage clotting [7]. While there are promising results regarding selenium's potential to reduce blood clots, many studies noted that further research is warranted to confirm the real-world applicability of these findings [3]. In conclusion, selenium supplementation does show scientific support for benefits related to blood clot prevention and treatment, but continued investigation is necessary to fully understand its potential and mechanisms.
Users have reported various improvements in symptoms while taking selenium, primarily in relation to thyroid function, cardiovascular health, and anti-inflammatory effects. Many individuals noted a reduction in muscle weakness and improved overall wellbeing, particularly those with thyroid disorders such as Hashimoto's disease. For example, after two months of taking selenium, one user experienced significant reductions in muscle weakness and twitches Read Review. Additionally, another review pointed out that users observed improvements in skin health and fewer symptoms related to inflammatory conditions like asthma Read Review.
Selenium is also recognized for its role in cardiovascular health, with users reporting benefits such as reduced cholesterol levels and enhanced blood flow, contributing to lower risks of blood clots and atherosclerosis Read Review. Furthermore, improvements in general health and energy levels were noted, including better hair and skin condition, as users reported stronger immune functions and enhanced recovery from illnesses Read Review. While experiences can vary significantly from one user to another, those who maintained consistent use over a few months tended to report the most noticeable enhancements in their health.
Based on user reviews, several individuals have reported positive experiences when combining selenium with other supplements for managing blood clot risks. One user mentioned taking selenium alongside zinc and quercetin, highlighting that this combination has effectively aided in blood thinning and overall health improvements Read Review. Additionally, users have shared that the cumulative effects of selenium, alongside other nutrients, can enhance cardiovascular health, lower cholesterol levels, and reduce inflammation, contributing to a decrease in blood clot formation and arterial plaque risks Read Review.
However, there is a note of caution; one user pointed out that selenium should be avoided prior to surgeries due to its potential impact on blood clotting Read Review. Overall, while users report beneficial interactions between selenium and other supplements, particularly for cardiovascular support, it is advised to consult with healthcare professionals when considering combining supplements, especially for underlying health conditions or before surgical procedures.
Users reported varying experiences regarding the right dose of selenium for treating issues related to blood clots. While the exact dosage recommendations were not specified in the reviews, many users indicated that they typically took selenium as part of a well-rounded regimen. For instance, one reviewer mentioned using selenium for about three months as per their endocrinologist's advice, highlighting the importance of professional guidance in determining the right dose for individual needs Read Review. Another user noted taking two tablets daily, which significantly alleviated symptoms related to their thyroid condition Read Review.
Several users echoed the benefits of selenium in thinning blood and preventing the formation of clots. They noted that it effectively helps lower bad cholesterol levels and supports vascular health Read Review. It’s clear from these reviews that while selenium has positive effects on blood thinning and cardiovascular health, the optimal dosage may vary based on individual health conditions and should ideally be personalized with the help of a healthcare professional.
7.5
Helps muscle weakness
2 people found this helpful
If you're dealing with thyroid issues, especially autoimmunity, consult your doctor about this! I have Hashimoto's, and it's helped me immensely. After a couple of months on two tablets daily, my muscle weakness and twitches have significantly decreased. They are easy to swallow and are well absorbed, as shown in my blood work.
6
Minor health improvements
My mother started taking selenium for her health due to hypothyroidism and hormone therapy. After a month, she observed some improvements: less frequent hair loss and more stable blood pressure. While memory issues persist, she feels a bit better overall. Though the effects aren't as pronounced as hoped, it gives us confidence that the product may help long-term.
7.5
Supports cardiovascular function
2 people found this helpful
This product demonstrates excellent absorption and concentration within the body. Consuming selenium-rich foods promotes cardiovascular health and its anti-inflammatory properties enhance blood flow while neutralising harmful free radicals. Studies indicate selenium reduces the risk of heart disease and lowers atherosclerosis incidents.
9
Blood thinning benefits
3 people found this helpful
This microelement thins the blood, thus preventing blood clots and reducing bad cholesterol levels. Selenium helps prevent atherosclerosis and positively affects the nervous system while offering anti-inflammatory benefits, assisting with asthma. I consistently use this selenium for my family's health.
7.5
Quality supplementation
1 people found this helpful
High-quality selenium thins the blood to reduce the risk of blood clots and lowers bad cholesterol levels. It effectively prevents atherosclerosis, supports the nervous system, and offers anti-inflammatory properties, aiding in asthma symptom relief.
6
Improves skin quality
1 people found this helpful
Selenium is prevalent in every human organ, strengthening protective functions with its antioxidant and anti-inflammatory properties. It activates circulatory system functions, strengthens blood vessels, and mitigates plaque risks. It also normalises immune activity, aids thyroid function, and fosters muscle and skin regeneration. I follow a course of selenium intake, and I've experienced significant improvements in my hair, nails, and skin condition.
7.5
Significantly beneficial
222 people found this helpful
I have recently started taking this microelement, and its benefits are undeniable. It thins the blood and lowers bad cholesterol, boasts anti-inflammatory properties, and positively impacts the nervous system. I think it helps with weight control and protects the thyroid gland. I take Selenium with Zinc and Quercetin—it’s my second time using this selenium cocktail, and I ordered it for both my husband and myself. The dosage seems appropriate. Selenium protects against free radical damage, prevents ageing, and reduces the risk of heart attacks and strokes.
7.5
Effective health support
This trace element thins the blood, consequently preventing the formation of blood clots and reducing harmful cholesterol levels. Selenium is beneficial in preventing atherosclerosis and exhibits anti-inflammatory properties, assisting those with high TSH levels. I take it for three months per my endocrinologist's advice. Highly satisfied!
2
Caution advised
1 people found this helpful
Selenium is a vital microelement, although not suitable for everyone. It aids in iodine absorption and boosts immunity, especially during colds. A deficiency can lead to chronic fatigue and irritability. However, one must avoid selenium before surgeries, as it may impair blood clotting.
9.5
Selenium-based therapy shows promise
Bionanoengineered 2D monoelemental selenene for piezothrombolysis.
We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
9.5
Ebselen delays blood clot formation
Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
7
Selenium may reduce blood clot risk
[Selenium, glutathione peroxidase, peroxides and platelet functions].
We explored the role of selenium in blood clotting, particularly its impact on platelets in people who are selenium-deficient. This research highlights how selenium helps manage the activity of glutathione peroxidase, an important enzyme in the body.
When selenium levels are low, platelets tend to become overly active, leading to increased clotting risks. However, we observed that selenium supplementation can enhance the activity of this enzyme, reducing platelet aggregation and potentially lowering the chances of thrombosis and heart disease.
About 10% of the population in France is selenium-deficient, so increasing selenium intake may provide health benefits in preventing vascular issues for these individuals.
9
Selenium polymer reduces blood clots
Multifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications.
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
References
Hu H, Xia L, Wang J, Huang X, Zhao Q, et al. Bionanoengineered 2D monoelemental selenene for piezothrombolysis. Biomaterials. 2024;305:122468. 10.1016/j.biomaterials.2024.122468
He F, Hou W, Lan Y, Gao W, Zhou M, et al. High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging. Int J Nanomedicine. 2023;18:4043. 10.2147/IJN.S404743
Mondal A, Douglass M, Hopkins SP, Singha P, Tran M, et al. Multifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications. ACS Appl Mater Interfaces. 2019;11:34652. 10.1021/acsami.9b10610
Arnaud J, Bost M, Vitoux D, Labarère J, Galan P, et al. Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites. J Am Coll Nutr. 2007;26:405.
Lindenblatt N, Schareck W, Belusa L, Nickels RM, Menger MD, et al. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression. Thromb Haemost. 2003;90:882.
Ricetti MM, Guidi GC, Tecchio C, Bellisola G, Rigo A, et al. Effects of sodium selenite on in vitro interactions between platelets and endothelial cells. Int J Clin Lab Res. 1999;29:80.
Vitoux D, Chappuis P, Arnaud J, Bost M, Accominotti M, et al. [Selenium, glutathione peroxidase, peroxides and platelet functions]. Ann Biol Clin (Paris). 1996;54:181.
Herrick AL, Rieley F, Schofield D, Hollis S, Braganza JM, et al. Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis. J Rheumatol. 1994;21:1477.
Perona G, Schiavon R, Guidi GC, Veneri D, Minuz P. Selenium dependent glutathione peroxidase: a physiological regulatory system for platelet function. Thromb Haemost. 1990;64:312.