Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9.5
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
Read More
7
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
Read More
7
Our study explored how selenium influences the interaction between platelets and endothelial cells, especially regarding blood clot formation. We noticed that selenium supplementation increased the activity of protective enzymes in both platelets and endothelial cells.
Interestingly, we found that platelets showed reduced aggregation in the presence of selenium-rich endothelial cells. However, this effect was nullified when we used aspirin, indicating a complex relationship. Ultimately, while selenium shows promise, we did not find significant improvements in nitric oxide levels linked to clot prevention.
Interestingly, we found that platelets showed reduced aggregation in the presence of selenium-rich endothelial cells. However, this effect was nullified when we used aspirin, indicating a complex relationship. Ultimately, while selenium shows promise, we did not find significant improvements in nitric oxide levels linked to clot prevention.
Read More
Most Useful Reviews
7.5
Helps muscle weakness
2 people found this helpful
If you're dealing with thyroid issues, especially autoimmunity, consult your doctor about this! I have Hashimoto's, and it's helped me immensely. After a couple of months on two tablets daily, my muscle weakness and twitches have significantly decreased. They are easy to swallow and are well absorbed, as shown in my blood work.
Read More
7.5
Effective health support
This trace element thins the blood, consequently preventing the formation of blood clots and reducing harmful cholesterol levels. Selenium is beneficial in preventing atherosclerosis and exhibits anti-inflammatory properties, assisting those with high TSH levels. I take it for three months per my endocrinologist's advice. Highly satisfied!
Read More
6
Minor health improvements
My mother started taking selenium for her health due to hypothyroidism and hormone therapy. After a month, she observed some improvements: less frequent hair loss and more stable blood pressure. While memory issues persist, she feels a bit better overall. Though the effects aren't as pronounced as hoped, it gives us confidence that the product may help long-term.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
- All Researches
9.5
We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
Read More
9.5
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
Read More
9
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
Read More
8
We investigated how selenium-based nanomaterials boost photoacoustic imaging to identify carotid artery blood clots more effectively. By using a thrombosis model in mice, we found that these nanocomposites significantly enhanced imaging signals—up to 5 times greater—which helps diagnose the extent of carotid atherosclerosis.
This research suggests that selenium/polypyrrole nanoparticles may be a promising tool for improving the detection and diagnosis of carotid thrombosis, potentially leading to better stroke prevention strategies.
This research suggests that selenium/polypyrrole nanoparticles may be a promising tool for improving the detection and diagnosis of carotid thrombosis, potentially leading to better stroke prevention strategies.
Read More
7
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helps muscle weakness
2 people found this helpful
If you're dealing with thyroid issues, especially autoimmunity, consult your doctor about this! I have Hashimoto's, and it's helped me immensely. After a couple of months on two tablets daily, my muscle weakness and twitches have significantly decreased. They are easy to swallow and are well absorbed, as shown in my blood work.
Read More
7.5
Effective health support
This trace element thins the blood, consequently preventing the formation of blood clots and reducing harmful cholesterol levels. Selenium is beneficial in preventing atherosclerosis and exhibits anti-inflammatory properties, assisting those with high TSH levels. I take it for three months per my endocrinologist's advice. Highly satisfied!
Read More
6
Minor health improvements
My mother started taking selenium for her health due to hypothyroidism and hormone therapy. After a month, she observed some improvements: less frequent hair loss and more stable blood pressure. While memory issues persist, she feels a bit better overall. Though the effects aren't as pronounced as hoped, it gives us confidence that the product may help long-term.
Read More
6
Better health overall
This is my first time using this brand, and I've been taking it for a while. It’s beneficial for cholesterol and I breathe more freely now, which has improved my overall health and blood thinning.
Read More
Frequently Asked Questions
7.5
Helps muscle weakness
2 people found this helpful
If you're dealing with thyroid issues, especially autoimmunity, consult your doctor about this! I have Hashimoto's, and it's helped me immensely. After a couple of months on two tablets daily, my muscle weakness and twitches have significantly decreased. They are easy to swallow and are well absorbed, as shown in my blood work.
6
Minor health improvements
My mother started taking selenium for her health due to hypothyroidism and hormone therapy. After a month, she observed some improvements: less frequent hair loss and more stable blood pressure. While memory issues persist, she feels a bit better overall. Though the effects aren't as pronounced as hoped, it gives us confidence that the product may help long-term.
7.5
Effective health support
This trace element thins the blood, consequently preventing the formation of blood clots and reducing harmful cholesterol levels. Selenium is beneficial in preventing atherosclerosis and exhibits anti-inflammatory properties, assisting those with high TSH levels. I take it for three months per my endocrinologist's advice. Highly satisfied!
9.5
We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
9.5
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
7
We explored the role of selenium in blood clotting, particularly its impact on platelets in people who are selenium-deficient. This research highlights how selenium helps manage the activity of glutathione peroxidase, an important enzyme in the body.
When selenium levels are low, platelets tend to become overly active, leading to increased clotting risks. However, we observed that selenium supplementation can enhance the activity of this enzyme, reducing platelet aggregation and potentially lowering the chances of thrombosis and heart disease.
About 10% of the population in France is selenium-deficient, so increasing selenium intake may provide health benefits in preventing vascular issues for these individuals.
When selenium levels are low, platelets tend to become overly active, leading to increased clotting risks. However, we observed that selenium supplementation can enhance the activity of this enzyme, reducing platelet aggregation and potentially lowering the chances of thrombosis and heart disease.
About 10% of the population in France is selenium-deficient, so increasing selenium intake may provide health benefits in preventing vascular issues for these individuals.
9
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
References
- Hu H, Xia L, Wang J, Huang X, Zhao Q, et al. Bionanoengineered 2D monoelemental selenene for piezothrombolysis. Biomaterials. 2024;305:122468. 10.1016/j.biomaterials.2024.122468
- He F, Hou W, Lan Y, Gao W, Zhou M, et al. High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging. Int J Nanomedicine. 2023;18:4043. 10.2147/IJN.S404743
- Mondal A, Douglass M, Hopkins SP, Singha P, Tran M, et al. Multifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications. ACS Appl Mater Interfaces. 2019;11:34652. 10.1021/acsami.9b10610
- Arnaud J, Bost M, Vitoux D, Labarère J, Galan P, et al. Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites. J Am Coll Nutr. 2007;26:405. PubMed
- Lindenblatt N, Schareck W, Belusa L, Nickels RM, Menger MD, et al. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression. Thromb Haemost. 2003;90:882. PubMed
- Ricetti MM, Guidi GC, Tecchio C, Bellisola G, Rigo A, et al. Effects of sodium selenite on in vitro interactions between platelets and endothelial cells. Int J Clin Lab Res. 1999;29:80. PubMed
- Vitoux D, Chappuis P, Arnaud J, Bost M, Accominotti M, et al. [Selenium, glutathione peroxidase, peroxides and platelet functions]. Ann Biol Clin (Paris). 1996;54:181. PubMed
- Herrick AL, Rieley F, Schofield D, Hollis S, Braganza JM, et al. Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis. J Rheumatol. 1994;21:1477. PubMed
- Perona G, Schiavon R, Guidi GC, Veneri D, Minuz P. Selenium dependent glutathione peroxidase: a physiological regulatory system for platelet function. Thromb Haemost. 1990;64:312. PubMed
Data last updated:
